Endocrine Abstracts

Introduction: Obesity is a complex and multifactorial disease with a chronic and relapsing nature, and is associated with over 200 co-morbidities. In a minority of patients, the obesity is caused by gene defects in the leptin-melanocortin pathway. As lifestyle interventions often fail in these patients, additional anti-obesity pharmacotherapy is needed. In this case report, we describe the therapeutic journey of a patient with early-onset obesity and hyperphagia due to heteroz...

The definitive treatment for Cushing’s disease is curative surgery. Patients with severe disease burden will likely require pre-operative medical blockade to reduce the risk of peri- and post-operative complications. The threshold for deciding when to medically block excess cortisol is currently based on clinical judgment. Expert centres may use a different criteria to determine this. There is no widely adopted tool for evaluating the clinical severity of Cushing’s d...

Objective: To determine the prevalence and characteristics of psychiatry inpatients with type 2 diabetes and pre-diabetes, compared to psychiatry inpatients without diabetes.Research design and methods: Inpatients aged >30 years at the Austin psychiatry unit (February 2014–April 2015) had HbA1c measurements as part of the Diabetes Discovery Initiative. Patients were divided into three groups – diabetes (HbA1c ≥6.5%, 48 mmol/mol), pre-...

Ectopic Cushing’s syndrome (CS) is commonly caused by malignancy, often behaves aggressively and may not clinically manifest with features of hypercortisolism due to its rapid course and associated cachexia. This may mislead clinicians into discounting the diagnosis in patients with more indolent features of CS. We present a 41 year old woman with an 8 year history of Cushingoid features with associated hypertension, obesity and Type 2 Diabetes. Investigations confirmed C...

Introduction: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, autonomic dysregulation, and neuro-endocrine tumour (ROHHAD-NET) is a rare syndrome associated with high morbidity and mortality. With no clear aetiology, diagnosis is based on constellation of clinical features. Management is supportive, although various immunosuppressive agents have been used with variable benefits. We present 3 cases of ROHHAD with heterogeneous presentations and clinical feat...

Introduction: Frimley Park Hospital, Surrey had been a negative HbA1c outlier for 3 consecutive years. The Children’s and Young People’s (CYP) diabetes team embarked upon the RCPCH National CYP Diabetes Quality Improvement (QI) Programme in November 2019. There was little qualitative data on ward nurse education, however, experience revealed engagement in staff training was the main barrier. Although regular education sessions were available to ward staff, attendance...

Introduction: Even Though resection via transsphenoidal surgery is the optimal primary treatment for growth hormone (GH) secreting pituitary adenomas, medical therapy must also be considered when biochemical control after surgery is not achieved. The aim of our study was to describe the cure rates of acromegaly patients after different lines of therapy.Methods: A retrospective study (1971–2022) of 89 patients diagnosed with acromegaly was conducted....

Background: Kisspeptin is an endogenous neuropeptide that regulates GnRH release from the hypothalamus. Kisspeptin-54 has been shown to effectively trigger oocyte maturation during in vitro fertilisation (IVF) treatment, but with markedly reduced rates of ovarian hyperstimulation syndrome (OHSS). The kisspeptin receptor agonist, MVT-602, has a longer half-life than native kisspeptin-54 (1.5–2.2 h vs. 0.5 h) and has potential for development as a novel trigger of oocyte ma...

Intracellular nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD salvage pathway. Abnormally elevated NAMPT can promote autoimmune and inflammatory processes. Many of these processes are key to type 1 diabetes (T1D) pathogenesis. Whilst NAMPT has been examined in other inflammatory diseases, the role of NAMPT in T1D remains unclear. To investigate the role of NAMPT in T1D, we used small molecule NAMPT modulators to determine the role of abnor...

Background: The NPDA has been providing annual audit reports to paediatric units in UK from 2003 and a compliance report for 7 care processes since 2016–2017. Over the years the focus on the type of data and implications of data has changed and become more focused especially after introduction of BPT and PEER review. The paediatric diabetes services at Basildon and Thurrock University Hospitals (BTUH) were identified as negative outliers in 2016–2017 NPDA report. A Q...